Fig. 7

Increased white matter integrity in microglial Nhe1 cKO and HOE642-treated mice at 30 days post-TBI. a, b Representative images of brains from rostral to caudal, and calculations of lesion volume and atrophy of T2 MRI of the ex vivo brains of Ctrl and cKO mice at 30 days post-TBI. c, d Representative DTI diffusion encoded color (DEC) map and analysis of FA in the white matter tracts (CC and EC) of the same cohort of mice in a. Colors hues represent the principle orientation of the diffusion tensor (red = left/right, blue = dorsal/ventral, and green = rostral/caudal) with the intensity weighted by the FA. e, f Representative images and calculations of lesion volume and atrophy of T2 MRI of the ex vivo brains of the Veh-control and HOE642-treated mice at 30 days post-TBI. g-h Representative DTI DEC map and analysis of FA in the white matter tracts of the same cohort of mice in e. Data are mean ± SEM. N = 4. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001