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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Microglial–oligodendrocyte interactions in myelination and neurological function recovery after traumatic brain injury

Fig. 8

Schematic illustration of microglial NHE1 protein activation in brain tissue damage/repair after TBI. TBI triggers NHE1 activation in both microglia and neurons. Specific inhibition of NHE1 protein in microglia not only reduced acute contusion volume and neurodegeneration, but also significantly ameliorated inflammatory microenvironment, promoting restorative microglial function and myelination after TBI. These outcomes were recapitulated with administration of a potent NHE1 inhibitor HOE642 post-TBI. Taken together, these findings demonstrated that blocking NHE1 protein stimulates restorative microglial activation in neuroprotection and oligodendrogenesis, which contributes to accelerated brain repair and neurological function recovery after TBI

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