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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Early effects of LPS-induced neuroinflammation on the rat hippocampal glycolytic pathway

Fig. 4

LPS induces mitochondrial impairment in the hippocampus. Oxygen consumption was measured in mitochondrial preparations from hippocampi. After 24 h, LPS reduced state 3 (ADP-stimulated) in the presence of metabolites PMC (A) and PMC + S (B) and state 4 (non-phosphorylating) in PMC + S (C). This time point decreases both uncoupled (CCCP-stimulated) (D, E) and the RCR (F). LPS 6 h (euthanized at 6 h after LPS administration), LPS 24 h (euthanized at 24 h after LPS administration). Values are expressed as means ± standard error. Data were analyzed by ANOVA, followed by the Tukey test, assuming P < 0.05. # means significant decrease, when compared to sham and LPS 6 h groups (# P < 0.05, ## P < 0.01)

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