Fig. 3
From: Mitochondrial dysfunction in microglia: a novel perspective for pathogenesis of Alzheimer’s disease
Mitochondrial QC in microglia. Mitochondrial QC is an important process in maintaining microglial homeostasis, mainly including mitochondrial fission, fusion, mitophagy, and MVBs. Microglia in AD are attacked by various pathogenic factors, including Aβ and p-Tau proteins, oxidative stress, ETC dysfunction, etc., which results in an imbalance of mitochondrial QC. The imbalanced microglial mitochondrial QC subsequently causes increased mitochondrial fragmentation, enhanced inflammatory factors release into the extracellular space, and excessive generation of ROS. These pathological changes further exacerbate inflammatory responses of microglia