Fig. 2

Reduced cytokine and chemokine levels in lumbar DRGs of SAFit2-treated SNI mice after 21 days. Mice underwent SNI surgery and were then treated with either vehicle or 10 mg/kg SAFit2 from day five to ten after the surgery. After 21 days, L4–L6 DRGs from ipsilateral and contralateral sides were isolated, lysed and tested in a multiplex immunoassay of 26 cytokines and chemokines. Shown is a section of significantly altered interleukins (A–G) and chemokines (K–P) after SAFit2 treatment. The data represent the mean ± SEM from 5 mice per group, measured in technical triplicates, respectively. The raw data were related to the total protein amount of the sample and the ipsilateral (injured) value was normalized to the contralateral (control) value per animal. *p < 0.05, **p < 0.01, ***p < 0.001 one-way ANOVA with Tukey´s post hoc test with multiple comparisons, comparing all treatments, respectively. SNI spared nerve injury, DRGs dorsal root ganglia, SAFit2 selective antagonist of FKBP51 by induced fit 2