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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: SAFit2 reduces neuroinflammation and ameliorates nerve injury-induced neuropathic pain

Fig. 9

Summary scheme of the neuronal and immunological effects of SAFit2. SAFit2 reduced the mechanical hypersensitivity of nerve-injured mice by enhancing the activity of the phosphatase calcineurin which diminishes the open probability of the TRPV1 channel and subsequent the release of the neuropeptide CGRP. On the immunological side SAFit2 reduces the activation of the NF-κB signaling pathway since it reduces the phosphorylation of the inhibitor complex IκBα and the p65 itself. In addition, SAFit2 reduces the infiltration of immune cells into DRGs and spinal cord as well as chemokine and cytokine levels in the respective tissues. In vitro, we also could confirm that SAFit2 reduces the migration of human and murine macrophages. The scheme was created with images from motifolio. SAFit2 selective antagonist of FKBP51 by induced fit 2, TRPV1 transient receptor potential cation channel subfamily V member 1, CGRP Calcitonin gene-related peptide, DRGs dorsal root ganglia, SC spinal cord, IκBα NF-κB inhibitor alpha, IKKβ IκB kinase beta

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