Fig. 4

Mefenamic acid improves the activity of mitochondrial respiratory chain complexes in the brain of septic animals. Sepsis was induced by cecal ligation and perforation and mefenamic acid (10, 30 and 50 mg/kg) was administered immediately after sepsis induction. Twenty-four hours after rats were euthanized and the prefrontal cortex and hippocampus were isolated to the determination of the activity of mitochondrial A–E complex I, B–F complex II, C–G complex II–III and D–H complex IV in frontal cortex (A–D) and hippocampus (E–H). Data are presented as mean ± SEM, with the statistical difference calculated using the one-way ANOVA test followed by Tukey's post hoc test. *p < 0.05 vs Sham + saline and ^#p < 0.05 vs CLP + saline. n = 5 per group