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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: ISGylation is induced in neurons by demyelination driving ISG15-dependent microglial activation

Fig. 7

Schematic summary of proposed model. A In response to demyelination neurons express and secrete ISG15. Induction of ISGylation also results in altered miRNA composition of secreted EVs. These EVs are taken up by surrounding neurons resulting in increased miRNA targeting of neuroprotective transcripts and reduced miRNA targeting of pro-apoptotic transcripts. B ISG15 secreted by neurons binds CD11b causing increased expression and secretion of proinflammatory cytokines. Additionally, EVs from ISG15 + neurons are also taken up by microglia resulting in reduced expression of anti-inflammatory transcripts such as A20

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