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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: TPM1 mediates inflammation downstream of TREM2 via the PKA/CREB signaling pathway

Fig. 6

TPM1 knockdown elicits inflammation-related transcriptomic alterations and cell death in the TREM2−/− retina. A, B Ingenuity Pathway Analysis (IPA) of top 20 canonical pathways in WT (A) or TREM2−/− mice (B) after treatments with LPS and siTPM1-1 or siCTR. p < 0.001. C, D DEGs in the phagosome formation pathway (C) and neuroinflammation signaling pathway (D) in TREM2−/− mice after treatments with LPS and siTPM1-1 or siCTR. E, F, TUNEL staining (E) and quantification of TUNEL-positive cells (F) in TREM2−/− mice following treatments with PBS, or with LPS and siTPM1-1 or siCTR. Data are presented as mean ± SEM and analyzed by one-way ANOVA with Tukey’s multiple comparison test (compared to PBS or LPS + siCTR, *p < 0.05, **p < 0.01, ***p < 0.001). n = 4 mice in each group. G, H qPCR analysis of Bax and Caspase-3 in TREM2−/− mouse retinas after treatments with LPS and siTPM1-1 or siCTR. Data are presented as mean ± SEM and analyzed by one-way ANOVA with Tukey’s multiple comparison test (compared to PBS or LPS + siCTR, *p < 0.05, ***p < 0.001, ****p < 0.001). n = 5 mice in each group

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