Fig. 5

Analysis of cell–cell communication patterns differences between Blank and I/R. Sankey plots showing the inferred outgoing communication patterns of secreting cells (A) and incoming communication patterns of target cells (B), which shows the correspondence between the inferred latent patterns and cell groups, as well as signaling pathways. The thickness of the flow indicates the contribution of the cell group or signaling pathway to each latent pattern. C Heatmap shows the role and importance of each cluster in IGF signaling network (up). Bar plots showing the relative contribution of each ligand–receptor pair in IGF signaling pathway (down). D Circle plot showing the inferred IGF signaling networks in Blank group. E Heatmap shows the role and importance of each cluster in NT signaling network (up). Bar plots showing the relative contribution of each ligand–receptor pair in NT signaling pathway (down). F Circle plot showing the inferred NT signaling networks between Blank and I/R groups. G Circle plot showing the inferred SEMA3 signaling networks between Blank and I/R groups. H Violin plots showing the expression of genes related to SEMA3 signaling between Blank and I/R groups. I Violin plots showing the expression of genes related to TNF signaling between Blank and I/R groups. J Circle plot showing the inferred CCL signaling networks in I/R group