Fig. 8

Neuroinflammation regulate the balance between hippocampal neuron death and neurogenesis in TD. NPC: neural progenitor cells; TD: thiamine deficiency; TPP thiamine pyrophosphate; H2A: histone 2A; H2B: histone 2B; H3: histone 3; H4: histone 4; K: lysine; R: arginine; P: phosphorylation; Ub: ubiquitination; Ac: acetylation; Me: methylation; H3K9me3: trimethylation in lysine 9 at histone 3; K3K4me3: trimethylation in lysine 4 at histone 3; TK: transketolase; PDHC: pyruvate dehydrogenase complex; Ogdh: oxoglutarate dehydrogenase; KGDHC: alfa-ketoglutarate dehydrogenase complex; PI3K/AKT: phosphatidylinositol 3-kinase/protein kinase B; BDNF: brain derived neurotrophic factor; H3K36me3: trimethylation in lysine 36 at histone 3; NSD1: nuclear receptor binding SET domain protein 1; SETD2: SET domain containing 2; Bmp4: bone morphogenetic protein 4