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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity

Fig. 4

Limited microstructural changes were observed in the cortex long-term. At P40, no change in the number of parvalbumin cells (A), their arborisation (B, C) or the number of detected synapses (D, E) were found. Directionality analysis of axonal fibres protruding into the cortex, identified from myelin basic protein immunohistochemistry (F, G), did show a significant difference in layer 5 of the cortex, but not upper layers (H, 2-way ANOVA). Data presented as mean ± SEM, *p < 0.05. Scale bars G = 100 µm. SAL: saline (n = 3); IL1: IL-1β (n = 3); IL + MO: IL-1β + montelukast (n = 4); MO: montelukast (n = 3)

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