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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1/RIP3/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma

Fig. 5

Activation of NLRP3 inflammasome triggered by glutamate excitotoxicity. a Protein levels of NLRP3 and NLRP3-related proteins in R28 cells after glutamate treatment. b Protein levels of NLRP3 and NLRP3-related proteins in the mouse retina after NMDA injury. c Representative immunofluorescence microphotographs of retinal sections stained with RBPMS (green), NLRP3 (red), and DAPI (blue) post-NMDA injection. Scale bar = 50 μm. GCL: ganglion cell layer; INL: inner nuclear layer; ONL: outer nuclear layer; CTL: the control group. The results were recorded as mean ± SD from at least three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 versus control or saline group. ns: not significant

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