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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Single cell profiling of CD45+ spinal cord cells reveals microglial and B cell heterogeneity and crosstalk following spinal cord injury

Fig. 2

Analysis of combined data across all timepoints reveals clusters containing major immune cell types. A UMAP embedding of all timepoints combined after normalization by SCTransform. Clusters clearly separated into distinct immune cell populations. Clusters 0, 1, 5 and 9 express canonical microglia markers. Cluster 2, 3 and 7 express B cell markers. Cluster 4 expresses markers of T cells, and cluster 8 expresses NK and NKT (simplified hereafter as NK-/T) cell markers. Cluster 6 expresses markers of monocytes/macrophages, and cluster 10 expresses granulocyte markers. B UMAP plots highlighting the localization of cells across timepoints. Red cells are the cells isolated on the day indicated. C Heatmap of the top five genes driving cluster separation. Macs macrophages, Monos  monocytes, NK Natural Killer cells, NKT Natural Killer T cells

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Journal of Neuroinflammation

ISSN: 1742-2094