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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Coexistence of chronic hyperalgesia and multilevel neuroinflammatory responses after experimental SCI: a systematic approach to profiling neuropathic pain

Fig. 9

Summary diagram. The data of this study (see details in Figs. 1, 2, 3, 4, 5, 6, 7 and 8) suggested that T10 compression in young adult female rats resulted in coexistence of chronic neuropathic pain (NP) and multilevel neuroinflammation, neurotransmission, neuroplasticity, and neuromodulation responses along the neuroaxis. Such injury-induced neural pathophysiological events in main spinal cord and brain sensory/pain processing centers have generated novel biomarkers as potential mechanistic underpinnings of SCI NP. The information can be used to multidimensionally profile experimental NP to enhance clinical relevance of pain modeling for therapeutic development

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