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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Constitutively active microglial populations limit anorexia induced by the food contaminant deoxynivalenol

Fig. 1

Effect of DON administration on IBA1 immunoreactivity within the hypothalamus and brainstem. A, B Representative images of IBA1-immunoreactivity in the hypothalamus (A) and brainstem (B) of control and DON-treated animals. Images originated from animals killed 6 h after treatment. High magnification images illustrate IBA1 immunoreactivity within two circumventricular organs, i.e., ME and AP and adjacent integrative nuclei ARC and NTS. Scale bars: 250 μm. C, D Quantitative analysis of IBA1 immunoreactivity performed at 3 and 6 h after treatment in selected regions of control and DON-treated animals. Histograms represented the number of IBA1 + cells per unit area (C) and the mean surface of IBA1 + cells (D). One-way ANOVA, *significantly different from respective control, *p < 0.05, **p < 0.01, ***p < 0.001. AP area postrema; ARC arcuate nucleus; cc central canal: ME median eminence; XII hypoglossal nucleus; NTS nucleus tractus solitarius. 3V: third ventricle

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