Fig. 4

MNs display altered mitochondrial structure between AR^−/− and WT mice at 1–14 d after BPRA injury. A Electron microscopy images of the ultrastructure of MNs in AR^−/− and WT mice at 1–14 d after BPRA injury. Colored triangle indicate mitochondria, green arrows indicate autophagic vacuoles. Representative images of mitochondrial classes I (purple triangle), II (green triangle), III (blue triangle), and IV (orange triangle) (B) and their quantitative distributions (C) in WT and AR^−/− mice. Quantitative graphs of the means ± SEM of mitochondria number/10 µm² (D) and autophagic vacuoles number (E). Quantification was performed in at least 20 different fields (> 150 mitochondria) per mouse, n = 5 mice/group. ^####p < 0.0001, WT vs. sham group, ^{^^^^}p < 0.0001, AR^−/− vs. sham group, ****p < 0.0001, WT vs. sham group