Fig. 8

Upregulation of 4-HNE-p-CREB in AR^−/− mice after BPRA injury. A, B Representative images of 4-HNE and p-CREB IF staining with microglia. C, D Number change in ipsilateral 4-HNE⁺ and p-CREB⁺ cells colocalization-positive to microglia between AR^−/− and WT mice. Data were analyzed by two-way ANOVA and are presented as the mean ± SEM, n = 5 mice/group, ^####p < 0.0001, WT vs. sham group, ^{^^^^}p < 0.0001, AR^−/− vs. sham group, ****p < 0.0001, WT vs. sham group