Fig. 11

Neuronal nuclear calcium signaling controls neuroinflammation in TBI. In normal conditions (empty vector), neuronal activity induces a transcriptional program that limits the induction of reactive microglia upon TBI and the associated loss of synapses. When neuronal nuclear calcium is inhibited, however, synaptic loss and microglial recruitment are strongly increased upon TBI, but these effects are reversed by the re-expression of Osteoprotegerin (OPG)