Fig. 6

Blunting neuronal nuclear calcium worsens acute motor disturbances upon TBI. A Representative images of analyzed mouse whiskers, showing the affected (red) and unaffected (blue) whiskers. B–E Representative traces depicting the angular position of the affected whiskers (red) compared to the unaffected (blue) whiskers over time. Decreased activity is seen at D1 post-injury in PV.NLS TBI mice, but not in the other treatment groups. F Significant decrease of whisker activity after nuclear calcium buffering in TBI compared to TBI alone 1d post-TBI (CT vs PT; 0.82 ± 0.08 vs 0.47 ± 0.09). The difference is no longer detectable at later timepoints. G No significant changes to the whisking activity of the unaffected whisker was observed. N = 8 per group. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001