Skip to main content
Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury

Fig. 7

Targeted transcriptome analysis reveals new neuronal nuclear calcium-regulated mediators of neuro–glia crosstalk after TBI. A Principal component analysis (PCA) plot showing distinct clustering of each treatment. B Volcano plot of PV.NLS TBI vs control TBI shows upregulation of genes related to disease-associated microglia (green) or complement system (blue) and a down regulation of genes related to synaptic function (red) and transcriptional regulation (purple) 3 h after TBI. C, D A subset of the 74 genes upregulated and 72 genes downregulated in the PV.NLS TBI vs control (C) and of the 65 genes upregulated and 81 genes downregulated in the PV.NLS TBI vs PV.NLS sham (D) is depicted. A complete list of significantly differentially expressed genes can be found in Additional file 7: Table S2

Back to article page