Fig. 1
From: The role of the ZEB1–neuroinflammation axis in CNS disorders
Zinc finger E-box binding homeobox 1 (ZEB1) represents a core transcriptional factor that controls essential intracellular processes. Upstream markers, including RAS/ERK, PI3X/AKT, NF-kB, JAK2/STAT3, Wnt/β-catenin, and Smad, lead to upregulation of ZEB1 via triggering ZEB1 directly or by mediation with TWIST, Snail and Slug. ZEB1 bilaterally is influenced via miR-200, miR200c, and miR-205. NF-kB also is involved in the upregulation of ZEB1 by repressing miR-200c. Transforming growth factor β (TGF-β), tumor necrosis factor (TNFα), Janus kinase 2(JAK2)