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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Genetic deletion of Krüppel-like factor 11 aggravates traumatic brain injury

Fig. 6

Genetic deletion of KLF11 increases pro-inflammatory microglia/macrophage polarization in mice after TBI. KLF11 KO and WT mice were subjected to TBI or sham operation and the activity of microglial polarization was examined in pericontusional brain regions at 3 d after TBI by double-immunostaining Iba-1 with CD16/32 (M1-phenotype) or CD206 (M2-phenotype). A Representative images of Iba-1 (green) and CD16/32 (red) double-immunofluorescence staining (rectangles: enlarged area of low-magnification images). B Quantitative analysis of Iba-1 and CD16/32 co-immunostained microglia/macrophages in experimental groups. C Representative images of Iba-1 (green) and CD206 (red) double-immunofluorescence staining (rectangles: enlarged area of low-magnification images). D Quantitative analysis of Iba-1 and CD206 co-immunostained microglia/macrophages in experimental groups. Data are presented as mean ± SD, n = 6/group. Statistical analyses were performed by one-way ANOVA with Tukey’s post hoc test. *p < 0.05, **p < 0.01 or ***p < 0.001 versus TBI + WT group

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