Fig. 8

KLF11 genetic deficiency in mice increases the inflammatory burden in post-trauma brains. KLF11 KO and WT mice were subjected to TBI or sham operation and a panel of 40 inflammatory mediators was measured in mouse brains at 3 d after CCI operation. A Array map of 40 inflammatory mediators. B Representative blots of the inflammatory array in experimental groups. C–K Quantitative analysis showed significantly increased inflammatory mediators in the brains of KLF11 KO mice in comparison with WT controls 3 d after TBI, including Eotaxin-2, FAS ligand, MIP-1-α, MIP-1-γ, RANTES, SDF-1, TNF-α, sTNF RI, and sTNF-RII. Data are presented as mean ± SD, n = 3–5/group. Statistical analyses were performed by one-way ANOVA with Tukey post hoc test. L A heatmap showing the mean expression levels of 40 brain inflammatory mediators in experimental groups. *p < 0.05, **p < 0.01 or ***p < 0.001 Sham + WT versus TBI + WT group. ^&p < 0.05, ^&&p < 0.01 or ^&&&p < 0.001 TBI + KO versus TBI + WT group