Fig. 3

Receiver operator characteristics (ROC) curve demonstrates the top 5 candidate proteins for each cluster are specific and sensitive to identify tauopathies. Using the PLS results and top 5 candidate proteins for each cluster, ROC curve was performed for A) CTE, B) AD, C) PSP, D) CBD, and E) AGD. The area under the curve (AUC), standard error, and significance is displayed below each graph. AUC values over 0.5 suggest positive association with each disease, while values under 0.5 represent negative association. The black line is the reference line. Multiple comparison correction set the significance threshold to p < 0.01