Table 2 Statistical analysis of cytokine levels in brain lysate
Brain cytokine statistics | ||||||
|---|---|---|---|---|---|---|
Analyte | Interaction F(df) | Interaction p | Treatment F(df) | Treatment p | Drug F(df) | Drug p |
IL-1a | F[1, 21] = 8.038 | 0.0099 | F[1, 21] = 3.223 | 0.087 | F[1, 21] = 6.292 | 0.0204 |
IL-6 | F[1, 21] = 8.823 | 0.0073 | F[1, 21] = 2.635 | 0.1194 | F[1, 21] = 12.51 | 0.002 |
IL-9 | F[1, 21] = 6.426 | 0.0193 | F[1, 21] = 5.718 | 0.0262 | F[1, 21] = 10.72 | 0.0036 |
IL-13 | F[1, 21] = 13.96 | 0.0012 | F[1, 21] = 6.627 | 0.0177 | F[1, 21] = 2.730 | 0.1133 |
IL-15 | F[1, 21] = 8.788 | 0.0074 | F[1, 21] = 0.4111 | 0.5284 | F[1, 21] = 6.226 | 0.021 |
IL-17 | F[1, 21] = 6.958 | 0.0154 | F[1, 21] = 4.310 | 0.0504 | F[1, 21] = 1.663 | 0.2112 |
G-CSF | F[1, 21] = 13.49 | 0.0014 | F[1, 21] = 23.16 |  < 0.0001 | F [1, 21] = 3.591 | 0.0719 |
INF-y | F[1, 21] = 27.88 |  < 0.0001 | F[1, 21] = 7.497 | 0.0123 | F[1, 21] = 4.560 | 0.0447 |
IP-10 | F[1, 21] = 5.875 | 0.0245 | F[1, 21] = 27.45 |  < 0.0001 | F[1, 21] = 3.743 | 0.0666 |
MKC | F[1, 21] = 0.7477 | 0.397 | F[1, 21] = 0.1538 | 0.6989 | F[1, 21] = 0.0077 | 0.9309 |
MCP-1 | F[1, 21] = 7.305 | 0.0132 | F[1, 21] = 12.17 | 0.0022 | F[1, 21] = 5.254 | 0.0323 |
RANTES | F[1, 21] = 12.65 | 0.0019 | F[1, 21] = 15.61 | 0.0007 | F[1, 21] = 3.828 | 0.0638 |
Bonferroni–ŠÃdák post-hoc analysis | ||||||
|---|---|---|---|---|---|---|
Analyte | SV vs. BV | SN vs. BN | SV vs. SN | BV vs. BN | SV vs. BN | BV. vs. SN |
IL-1a | 0.0397 | > 0.9999 | > 0.9999 | 0.0094 | > 0.9999 | 0.0273 |
IL-6 | 0.0419 | > 0.9999 | > 0.9999 | 0.0014 | > 0.9999 | 0.0062 |
IL-9 | 0.0254 | > 0.9999 | > 0.9999 | 0.0044 | > 0.9999 | 0.0025 |
IL-13 | 0.003 | > 0.9999 | 0.834 | 0.0087 | > 0.9999 | 0.0311 |
IL-15 | 0.173 | 0.5034 | > 0.9999 | 0.0078 | > 0.9999 | 0.185 |
IL-17 | 0.035 | > 0.9999 | > 0.9999 | > 0.0860 | > 0.9999 | 0.1291 |
G-CSF | 0.0001 | > 0.9999 | > 0.9999 | 0.0065 | 0.3633 | 0.0004 |
INF-y | 0.0002 | 0.3617 | 0.1826 | 0.0003 | > 0.9999 | 0.0102 |
IP-10 | 0.0004 | 0.2353 | > 0.9999 | 0.0446 | 0.2133 | 0.0002 |
MKC | > 0.9999 | > 0.9999 | > 0.9999 | > 0.9999 | > 0.9999 | > 0.9999 |
MCP-1 | 0.0036 | > 0.9999 | > 0.9999 | 0.0164 | > 0.9999 | 0.0021 |
RANTES | 0.0005 | > 0.9999 | > 0.9999 | 0.0071 | > 0.9999 | 0.0017 |