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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Hippocampal microRNA-26a-3p deficit contributes to neuroinflammation and behavioral disorders via p38 MAPK signaling pathway in rats

Fig. 1

Knock-down of miR-26a-3p in hippocampus caused behavioral disorders in rats. A The expression of miR-26a-3p in CA1 hippocampal region in animal models. B The expression of miR-26a-3p in DG hippocampal region in animal models. C The expression of miR-26a-3p in vmPFC in animal models. D Schematics of AAV vectors engineered to knock-down miR-26a-3p and the experimental paradigm. E Illustration of AAV viral infusion into the hippocampal region. Scale bar is 2 mm. F Expression level of miR-26a-3p in the hippocampus. G Motion traces of rats in the open field test (OFT). H Total distance in the OFT was decreased after knock-down of miR-26a-3p. I Time spent exploring the center area was decreased after knock-down of miR-26a-3p. J Motion traces of rats in the elevated plus maze (EPM). K The number of entering open arms was decreased in miR-26a-3p knock-down rats. L Time spent in the open arms (%) was decreased in miR-26a-3p knock-down rats. M The immobility times in forced swim test (FST) were increased in miR-26a-3p knock-down rats. N The swimming times in FST was decreased in miR-26a-3p knock-down rats. O The percent of sucrose consumption was decreased in sucrose preference test. Data are presented as the means ± SEMs. N = 8 per group. NS, not significant (P > 0.05); *P < 0.05, **P < 0.01, ***P < 0.001

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