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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: An AGS-associated mutation in ADAR1 catalytic domain results in early-onset and MDA5-dependent encephalopathy with IFN pathway activation in the brain

Fig. 3

Age-dependence of brain ISG expression in Adar D1113H mutant mice. A Newborn mice exhibited heightened expression of ISGs compared with WT mouse brains. B Expression at 2 weeks remained elevated, increasing for some ISGs. C Comparison of ISG expression in brains at 2 versus 8 weeks. Pairwise comparisons between genotypes or ages for each ISG was performed using Mann–Whitney U test (n = 4–6 per group)

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Journal of Neuroinflammation

ISSN: 1742-2094