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Table 3 Concentration of cytokines/chemokines after LPS stimulation

From: Evidence of innate immune dysfunction in first-episode psychosis patients with accompanying mood disorder

  

HC

AFF

NON

Median

(IQR)

Median

(IQR)

Median

(IQR)

Growth factors

G-CSF

7004

(3616–10,607)

5839

(3855–11,409)

7026

(3560–10,522)

GM-CSF

951.5

(411.9–1662)

2076#

(863.6–2998)

1157

(758.4–2120)

IL-7

147.1

(97.3–220.9)

130.4

(91.93–253.3)

149.5

(81.36–219)

Innate inflammatory cytokines

TNF-α

667.3

(307.1–1665)

1081*

(475–2501)

549.8

(265.9–1206)

TNF-β

10.07

(7.21–18.99)

18.430

(10.46–30.52)

13.73

(7.79–20.32)

IL-1α

676.5

(417.6–931.3)

979.1

(375.7–1274)

621.2

(423.4–1001)

IL-1β

872.3

(478.3–1708)

1884

(499.7–2849)

932.4

(499.4–1326)

IL-6

24,378

(17,727–34,327)

25,326

(18,675–28,548)

22,498

(9904–28,025)

IL-15

2.045

(0.6–6.293)

2.365

(0.6–5.453)

5.39*†

(2.958–13.53)

IFNα2

65.52

(44.42–89.09)

93.99

(42.76–168.3)

91.28†

(65–139.3)

Innate inflammatory chemokines

Eotaxin

232.7

(172–388.3)

325.6*

(227.8–657.8)

226.6

(179.4–312.5)

IL-8

28,706

(22,063–42,134)

32,535

(29,256–42,602)

29,426

(22,479–38,281)

IP-10

123.6

(94.64–163.4)

173.7

(103.4–299.4)

117.2

(92.26–178.3)

MCP-1

21,723

(12,959–28,732)

20,693

(16,627–23,984)

18,618

(8496–22,436)

MIP-1β

2863

(351.6–5706)

3781

(1342–7966)

2291

(1241–5973)

TH1 cytokines

IFNγ

163.1

(116.5–273.6)

251.3

(178.3–424.4)

166.7

(133.8–283.5)

IL-2

9.75

(4.65–14.7)

11.7

(5.085–26.12)

10.82

(6.228–26.73)

IL-12p40

229.3

(151.9–287.5)

292.5

(92.7–501)

249.6

(176.4–328.5)

IL-12p70

106.9

(48.68–126)

110.5

(48.35–208)

97.32

(61.34–130.6)

TH2 cytokines

IL-4

14.66

(7.29–27.71)

19.59

(7.705–57.5)

20.34

(12.96–45.41)

IL-5

3.3

(0.25–5.36)

2.97

(0.25–4.52)

3.42

(0.465–5.375)

IL-13

29

(14.2–46.44)

33.33

(16.71–86.75)

26.02

(19.9–42.24)

TH17 cytokine

IL-17

17.04

(8.29–20.41)

20.91#

(10.73–53.02)

14.53

(9.393–21.33)

Regulatory cytokines

IL-10

1321

(654–2257)

1071

(302.4–1709)

1228

(594.4–1654)

TGF-β

2063

(1213–3724)

1893

(911.4–3610)

2728

(1763–3831)

  1. # p value < 0.05 when comparing AFF with HC
  2. * p value < 0.05 when comparing AFF with NON
  3. † p value < 0.05 when comparing NON with HC