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Table 4 Concentration of cytokines/chemokines after PHA stimulation

From: Evidence of innate immune dysfunction in first-episode psychosis patients with accompanying mood disorder

  

HC

AFF

NON

Median

(IQR)

Median

(IQR)

Median

(IQR)

Growth factors

G-CSF

1073

(176.2–5540)

1742

(507.6–3131)

1568

(502.1–3992)

GM-CSF

2052

(1068–4299)

2688

(1174–7231)

2144

(1210–4119)

IL-7

230.8

(155.2–356.2)

212.6

(174.7–364.8)

207.8

(153.6–376.2)

Innate inflammatory cytokines

TNF-α

1788

(660–3352)

2935

(1398–5679)

1439

(744.5–3003)

TNF-β

132.4

(45.81–249.9)

90.850

(60.01–225.2)

94.32

(52.81–259.4)

IL-1α

255.1

(119.7–483.3)

260.3

(142.4–490.1)

147

(71.45–383.6)

IL-1β

397

(163.2–701.5)

435.8

(294.9–924.8)

423.1

(185.2–666.8)

IL-6

12,379

(4432–32,676)

14,652

(10,115–38,533)

14,463

(8887–29,259)

IL-15

BLD

( -)

BLD

( -)

BLD

( -)

IFNα2

143.5

(107.3–255.6)

169.3

(105.9–271.6)

233.9

(94.19–308.3)

Innate inflammatory chemokines

Eotaxin

437.1

(332.3–538.4)

579.6#

(427.6–1159)

491.5

(390.6–721.6)

IL-8

58,839

(45,963–72,654)

72,251

(60,626–79,861)

62,381

(46,572–73,048)

IP-10

1636

(737.4–2676)

674.7

(507.4–1881)

1110

(346.7–2251)

MCP-1

45,328

(32,987–56,223)

46,623

(40,973–53,608)

42,272

(36,682–55,723)

MIP-1β

8413

(3240–14,641)

9661

(4050–17,779)

6455

(2483–11,844)

TH1 cytokines

IFNγ

1173

(561.6–8849)

4341*

(1063–11,102)

851.6

(450.8–1678)

IL-2

38.67

(19.71–88.13)

43.55

(21.72–94.29)

34.23

(22.01–85.62)

IL-12p40

469.1

(279.1–550.6)

463.9

(314.4–679.1)

416.5

(317.4–586.8)

IL-12p70

233.7

(122.4–339.8)

257.7

(126.7–344.4)

212.6

(117.7–255.6)

TH2 cytokines

IL-4

54.87

(25.72–83.06)

95.57

(37.74–124.6)

64.69

(34.19–111.5)

IL-5

31.31

(5.283–55.71)

37.21

(12.36–66.15)

29.31

(5.013–70.01)

IL-13

547

(189.5–1356)

920.7

(273.3–2179)

845.5

(232.2–1494)

TH17 cytokine

IL-17

171.8

(109.4–261.1)

225.2

(114.4–336.9)

198.8

(113–415.3)

Regulatory cytokines

IL-10

634.2

(267.4–1287)

534.4

(306.3–918.8)

547.6

(233–1017)

TGF-β

2460

(1253–3338)

2056

(1233–4097)

2530

(1506–3467)

  1. BLD below the limit of detection
  2. # p value < 0.05 when comparing AFF with HC
  3. * p value < 0.05 when comparing AFF with NON
  4. † p value < 0.05 when comparing NON with HC