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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Microglial diversity along the hippocampal longitudinal axis impacts synaptic plasticity in adult male mice under homeostatic conditions

Fig. 1

Hippocampal LTP in the two poles is influenced by microglia. Time course of normalized averaged amplitudes of fEPSPs recorded from CA1 region of dorsal and ventral hippocampal slices in A control, B minocycline, C PLX5622, D Cx3cr1−/− groups following Schaffer collateral high-frequency stimulation (HFS, 2 trains of stimuli at 100 Hz of 1 s duration each, 3 s inter-train interval, arrow). Symbols represent mean ± S.E.M. of normalized fEPSP amplitude evoked every 20 s. Above are representative traces taken before (grey) and after (black) HFS from each region. Comparison of the mean LTP amplitude, recorded at 35 min after HFS, between experimental groups in dorsal (E) and ventral (F) hippocampus. Dots represent individual slices. Statistical significance was assessed by t-test and one-way ANOVA, Holm–Sidak for post hoc comparison. *p < 0.05, **p < 0.01, ***p < 0.001

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