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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Parabiosis reveals the correlation between the recruitment of circulating antigen presenting cells to the retina and the induction of spontaneous autoimmune uveoretinitis

Fig. 1

Progression of spontaneous autoimmune uveoretinitis (SAU). A Histopathological scoring of SAU in R161H+/− (B10.RIII) mice (open circles, n = 16) and R161H+/− × B6/J F1 mice (closed circles, n = 11) at days 23–40 of age (left panel, with mean ± SD indicated) and for R161H+/− × B6/J F1 mice greater than 50 days of age (right panel, n = 29). Each data point represents one retina from one mouse. Number adjacent to data points represents number of retinas with that severity of SAU at that time point. For mice 23–40 days of age, statistical comparison between R161H+/− (B10.RIII) and R161H+/− × B6/J F1 mice was done by Fisher’s exact test for incidence and by t test for severity. B Representative histopathology in R161H+/− × B6/J F1 mice over the course of disease. Right (OD) and left (OS) retinas from one mouse at indicated time point shown. Arrows on day 36 panel indicate initial minor pathology. C Brightfield fundoscopy of retinas from B showing clinical SAU

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