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Table 1 Parabiotic transfer of spontaneous autoimmune uveoretinitis (SAU)

From: Parabiosis reveals the correlation between the recruitment of circulating antigen presenting cells to the retina and the induction of spontaneous autoimmune uveoretinitis

Pairing condition

SAU incidencea

ρ valueb

Donor < 67 days of agec

2/10

0.0180 vs. 71–165 days of age

Donor 71–165 days of age

10/14

 

Donor > 175 days of age

0/5

0.0108 vs. 71–165 days of age

Donor: no or sub-clinical SAUc

1/8

0.0119 vs. active SAU

Donor: active SAU

10/14

 

Donor: resolving SAU

1/7

0.0208 vs. active SAU

Paired 20–38 days

1/6

0.1824 vs. paired 43–153 days

Paired 43–57 days

6/11

0.1595 vs. paired 20–38 days

Paired 58–153 days

5/12

0.3058 vs. paired 20–38 days

Recipient: 44–63 days of agec

1/6

0.1824 vs. 64–177 days of age

Recipient: 64–85 days of age

3/10

0.5110 vs. 44–63 days of age

Recipient: 86–177 days of age

8/13

0.0913 vs. 44–63 days of age

Recipient retina outcomes

Occurrenced

ρ valueb

GFPhi cell positive

19/29

 

SAU positive

12/29

 

SAU positive/GFPhi cell positive

12/19

0.0010 vs. GFPhi cell neg/SAU pos

GFPhi cell negative

10/29

 

SAU positive/GFPhi cell negative

0/10

 
  1. R161H+/− × CD11cDTR/GFP F1 (donor) joined with B10.RIII × B6/J F1 (wild-type recipient)
  2. aNumber of pairs with SAU positive recipients/total pairs for specified donor or recipient condition
  3. bρ value determined by Fisher’s exact test
  4. cAge or SAU status at time of joining
  5. dNumber of recipient retinas with specified outcome/total pairs or pairs with specified GFPhi cell outcome