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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Upregulated complement receptors correlate with Fc gamma receptor 3A-positive natural killer and natural killer-T cells in neuromyelitis optica spectrum disorder

Fig. 1

Flow cytometry analysis of NK and NKT cells. Although there is no change in the abundance of NK cells themselves (A), CD16-positive NK cells are significantly decreased in NMOSD (B). Complement receptors CD35 (C) and CD88 (D) were increased in NMOSD, and CD35 + CD88 + co-positive cells were markedly increased (E). Activation markers CD69 (F) and CD83 (G) were also increased in NK cells. Analysis of NKT cells showed they were significantly increased in NMOSD (H), while CD16-positive cells (I) and TCR Vα24-positive cells (O) were significantly decreased. CD88 (K) and CD35 + CD88 + double-positive (L) showed significant increases compared to NC, while CD35 (J) and activation markers (M, N) were unchanged. NMOSD (n = 45), disease controls (n = 18), and healthy controls (n = 19). *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001

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