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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Upregulated complement receptors correlate with Fc gamma receptor 3A-positive natural killer and natural killer-T cells in neuromyelitis optica spectrum disorder

Fig. 6

Analysis of parameters among FcGR3A p158 polymorphisms in NMOSD. The percentage of NK cells (A–F) and NKT cells (G–M) is shown among NMOSD patients with V/V, V/F, and F/F genotypes. The ratio of NK cells in total PBMCs was significantly decreased in the V/V genotype group compared to the F/F group (A). There was no difference in the expression of CD16 (B), CD35 (C), and CD83 (F) in these cells, but CD69-positive NK cells were significantly increased (E), and CD88-positive NK cells were significantly increased in the V/V group compared with the V/F group (D). Meanwhile, there was no difference in the ratio of NKT cells (G), but CD16-positive NK cells were decreased in the V/V group (H). Furthermore, TCR Vα24-positive NKT cells were significantly increased in the F/F group compared to the V/F group (M), and there was also a tendency for an increase in the F/F group compared to the V/V group (p = 0.0861). The expression of CD35 in NKT cells was also significantly decreased in V/V group than F/F group (I). There was no difference in complement receptors or activation markers on the surface of NKT cells between the groups (J–L). *p < 0.05; **p < 0.01

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