Fig. 1
From: Saturated very long-chain fatty acids regulate macrophage plasticity and invasiveness
RNA-seq transcriptional profiling of X-ALD macrophages reveals alterations in genes associated with the immune response. A Volcano plot depicting differentially expressed genes belonging to the inflammatory response Gene Ontology Term (GO:0006954) of macrophages, derived by in vitro differentiation of monocytes from X-ALD patients compared to healthy controls (n = 9 for each). Red-coloured dots represent upregulated genes, whereas downregulated genes are indicated in blue. The fold change and the adjusted p-values are indicated on a log2 and log10 scale, respectively. Differentially expressed genes with either log2 fold changes higher than ± 0.6 or − log10 adjusted p-values higher than 18 were tagged with the indicated gene symbol. B Interactome graph of the inflammatory response Gene Ontology Term (GO:0006954) of macrophages derived from X-ALD patients compared to healthy controls (n = 9 for each). Nodes depict genes, while edges show protein–protein interactions between gene products. The colour of nodes depicts log2 fold change, with red indicating upregulated, blue downregulated and grey non-differentially expressed genes. The frequency of protein–protein interaction is reflected by the size of the node