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Fig. 10 | Journal of Neuroinflammation

Fig. 10

From: Sirtuin 5 aggravates microglia-induced neuroinflammation following ischaemic stroke by modulating the desuccinylation of Annexin-A1

Fig. 10

Schematic diagram representing the mechanism by which SIRT5 inhibition protects neurons against cerebral I/R injury by regulating microglia-induced neuroinflammation. The increase in SIRT5 in microglia induced by ischaemic stroke causes ANXA1 desuccinylation, which decreases ANXA1 membrane recruitment and secretion but promotes ANXA1 nuclear translocation, resulting in the production of proinflammatory mediators and ultimately enhancing neuroinflammation damage. Thus, SIRT5 ablation might protect against neuronal damage induced by cerebral I/R injury

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