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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: NLRP3 deficiency decreases alcohol intake controlling anxiety-like behavior via modification of glutamatergic transmission in corticostriatal circuits

Fig. 3

NLRP3 cascade signaling and neuron injury in the mPFC and striatum occurred after binge drinking-induced anxiety-like behavior. A Nissl bodies were stained by the Nissl staining. Scale bar = 50 μm. WT + alcohol group showed less Nissl bodies than the WT group and NLRP3 KO + alcohol group displayed more Nissl bodies than the WT + alcohol group in both mPFC and striatum, *p < 0.05, ***p < 0.001 vs WT group, #p < 0.05, ###p < 0.001 vs WT + alcohol group, one-way ANOVA, 3 mice per group, 3 slices per mice. B The samples showing the expression of caspase-1 in the mPFC (left) and striatum (right). C The statistics of the expression of caspase-1 in the mPFC (left) and striatum (right), *p < 0.05 vs WT group, #p < 0.05 vs WT + alcohol group, one-way ANOVA. D Histogram summary of expression of IL1-β in the mPFC and striatum; *p < 0.05 vs WT group, #p < 0.05, ##p < 0.01 vs WT + alcohol group, one-way ANOVA, n = 3–7 mice for each group. E. Histogram summary of TNFα in the mPFC and striatum, #p < 0.05 vs WT + alcohol group, one-way ANOVA, n = 4–5 mice for each group. Data are presented as mean ± SEM

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