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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: NLRP3 deficiency decreases alcohol intake controlling anxiety-like behavior via modification of glutamatergic transmission in corticostriatal circuits

Fig. 4

NLRP3 deficiency decreased the potentiated NMDAR-mediated glutamatergic transmission caused by binge drinking. A Experimental timeline of DID + gavage training, behavior and electrophysiology tests. B Schematic illustration of the electrical stimulation and the recording of striatal neurons. C Sample traces showing paired-pulse ratios from three groups. D Averaged data illustrating a decrease of PPR after binge drinking and an increase in NLRP3 KO + alcohol group compare to WT + alcohol group. *p < 0.05 vs. WT group, #p < 0.05 vs WT + alcohol group, one-way ANOVA, n = 8–11 neurons. E Sample traces showing NMDAR/AMPAR ratio from three groups. F Averaged data showing the NMDAR/AMPAR ratio was significantly increased in WT + alcohol group compared to the WT group. The ratio was decreased by NLRP3 KO treatment compared to the WT + alcohol group. *p < 0.05 vs. WT group, #p < 0.05 vs. WT + alcohol group, one-way ANOVA, n = 16–20 neurons. Data are presented as mean ± SEM

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Journal of Neuroinflammation

ISSN: 1742-2094