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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Zika virus infection of mature neurons from immunocompetent mice generates a disease-associated microglia and a tauopathy-like phenotype in link with a delayed interferon beta response

Fig. 6

ZIKV-infection induces a DAM-like phenotype in the brain of immunocompetent CC071 mice susceptible to infection. CC001 and CC071 mice (5–6 week-old) were necropsied at day 6 following IC inoculation of either PBS or 105 FFU of ZIKV. In the brain of CC071 as compared to CC001 mice, ZIKV affects the level of RNA expression of genes associated with a DAM phenotype as determined by RT-qPCR analysis of total brain extracts from ZIKV-infected CC001 and CC071 mice with respect to Hrpt1 used as reference gene. Symbols represent individual mice. Data from n = 5 CC001 and CC071 mice respectively are means without s.d. with significance assessed by two-way ANOVA and Tukey’s multiple comparisons test. P-value < 0.0001 (****), < 0.001 (***), < 0.01 (**) and ns not significant

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Journal of Neuroinflammation

ISSN: 1742-2094