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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Low-dose brain irradiation normalizes TSPO and CLUSTERIN levels and promotes the non-amyloidogenic pathway in pre-symptomatic TgF344-AD rats

Fig. 4

Mechanisms of LD-RT effects in the brain of pre-symptomatic TgAD rats. LD-RT treatment (10 Gy delivered in 5 daily fractions of 2 Gy) led to a drastic reduction of soluble and aggregated forms of amyloid peptides. This reduction is not due to an increase of the amyloid production. In addition, the non-amyloidogenic pathway was promoted by LD-RT. Finally, a restoration of on neuroinflammatory marker levels was measured. Altogether, those mechanisms could favor neuronal survival in TgAD rats. Solid lines indicated results demonstrated in this study. Dashed lines indicated hypothetical mechanisms

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