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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Delayed NLRP3 inflammasome inhibition ameliorates subacute stroke progression in mice

Fig. 2

NLRP3 inhibition reduces stroke severity, secondary infarct growth, mortality and improves functional outcome as a long-term effect after prophylactic and delayed treatment 24 h after stroke onset. A Infarct volumetry (n ≥ 7) and B representative 2,3,5-triphenyltetrazolium chloride stainings of 3 consecutive coronal brain sections of vehicle-, MCC950 d0- and MCC950 d1-treated mice euthanized 7 days after tMCAO. In addition, infarct volumetry was performed 1 day after tMCAO of vehicle treated animals to visualize infarct progression between days 1 and 7. Scale bar = 2 mm. The infarcts are circled by a blue line. Data were analyzed by one-way ANOVA with post hoc Tukey adjustment for p values. *p < 0.05; ***p < 0.001. C Survival curve of vehicle-, MCC950 d0- and MCC950 d1-treated mice over a reperfusion period of 7 days. A log-rank test was performed to assess whether significant differences exist between the three study groups. Results show that survival distributions of the three interventions differ significantly, χ2 = 10.25, *p < 0.05. D The Neuro Score, E the modified Neurological Severity Scores (mNSS) and F the Latency To Move Test were performed on the day of tMCAO as well as daily during the 7 days of reperfusion (n ≥ 8). Data were analyzed by two-way ANOVA with post hoc Tukey adjustment for p values. *p < 0.05; **p < 0.01; ***p < 0.001

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