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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Fecal microbiota transplantation and replenishment of short-chain fatty acids protect against chronic cerebral hypoperfusion-induced colonic dysfunction by regulating gut microbiota, differentiation of Th17 cells, and mitochondrial energy metabolism

Fig. 5

The potential molecular mechanisms involved in the FMT and SCFAs treatment in colon. A, C Histogram of the significantly enriched GO or KEGG terms in BCCAo group vs. BCCAo + FMT group and BCCAo group vs. BCCAo + SCFAs group respectively according to RNA sequencing datasets. The horizontal coordinate represents − log10 (p-value), the vertical coordinate represents GO or KEGG names. B, D Volcano plots showing partial differentially expressed genes (DEGs) in the above pathways we are interested in in BCCAo group vs. BCCAo + FMT group and BCCAo group vs. BCCAo + SCFAs group respectively according to RNA sequencing datasets. The horizontal axis indicates log2 (fold change), the vertical axis indicates −log10 (p-value). Some DEGs passed the verification of western blot are marked with names. E Gene set enrichment analysis (GSEA) performed in BCCAo group vs. BCCAo + SCFAs group based on RNA sequencing datasets. The total height of the curve reflects the extent of enrichment, the normalized enrichment score (NES) and norminal p value are indicated

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Journal of Neuroinflammation

ISSN: 1742-2094