Fig. 5

CCR2 attenuated the neuroinflammation and neuronal apoptosis after SAH. A The expression of CCR2 was significantly reduced in the ipsilateral cortex by RS at 24 h after SAH. B–D Inhibition of CCR2 using RS improves neurological and reduces brain edema and EB extravasation at 24 h following SAH. E–I Representative western blot bands and densitometric quantification of Blc-2, and Bax, IL-1β, TNF-α in the ipsilateral hemisphere at 24 h after SAH, n = 6 per group. J, K The concentrations of IL-1β and TNF-α in ipsilateral cortical tissue after homogenization were determined by ELISA. L–O Representative images of TUNEL staining and quantification of TUNEL-positive neurons in cortex and hippocampus tissues. Veh, PBS containing 10% DMSO. *P < 0.05 vs Sham group. **P < 0.01 vs Sham group. ^#P < 0.05 vs SAH group. ^##P < 0.01 vs SAH group. Scale bars = 50 μm