Fig. 7

LY reversed the protective effects of RS at 24 h after SAH in mice. A–C LY aggravates neurological and increases brain edema and EB extravasation at 24 h following SAH treated with RS. D Representative western blot bands. E–L Densitometric quantification of CCR2, p-PI3K, PI3K, p-AKT, AKT, Bcl-2, Bax, and CC3, IL-1β and TNF-α in the ipsilateral hemisphere at 24 h after SAH. Data were represented as mean ± SD. Veh, PBS containing 10% DMSO. *P < 0.05 vs Sham group; **P < 0.01 vs Sham group. ^#P < 0.05 vs SAH group. ^##P < 0.01 vs SAH group; ^&P < 0.05 vs. SAH + RS and SAH + RS + DMSO group; ^&&P < 0.01 vs. SAH + RS and SAH + RS + DMSO group; n = 6 per group