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Table 1 Upregulated genes of the most altered pathways in reactive astrocytes

From: Protein kinase B (AKT) upregulation and Thy-1-αvβ3 integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis

Accession number

Gene

Fold

P value

PI3K/AKT signaling pathway

X75483

Cyclin A2

3.57

2.0E−07

AK013312

Cyclin B2

2.86

1.3E−03

NM007659

Cyclin-dependent kinase 1

2.82

2.9E−06

NM007629

Cyclin B1/predicted gene 5593

2.00

7.2E−04

AU015121

Cyclin B1

1.96

6.2E−03

NM009873

Cyclin-dependent kinase 6

1.67

1.5E−05

NM011146

Peroxisome proliferator activated receptor gamma

1.42

4.9E−05

BM935811

Integrin alpha 6

1.32

6.5E−08

NM010576

Integrin alpha 4

1.32

6.0E−03

AF091432

Cyclin E2

1.30

2.0E−04

NM016756

Cyclin-dependent kinase 2

1.18

5.4E−04

AF032460

BCL2-like 11 (apoptosis facilitator)

1.11

1.3E−03

NM007634

Cyclin F

1.10

1.3E−02

BB768208

Serum/glucocorticoid regulated kinase 3

1.03

6.7E−05

NM011905

Toll-like receptor 2

0.93

9.8E−03

BM120341

Integrin beta 1 (fibronectin receptor beta)

0.92

5.7E−06

NM007633

Cyclin E1

0.88

1.4E−02

NM008396

Integrin alpha 2

0.84

3.4E−03

NM016746

Cyclin C

0.73

5.7E−06

BC003828

RAS-related C3 botulinum substrate 1

0.70

1.0E−06

NM023243

Cyclin H

0.67

8.5E−09

U95826

Cyclin G2

0.62

1.7E−04

BB051001

Cyclin J

0.61

8.4E−04

BG070845

Cyclin-dependent kinase 12

0.60

1.1E−02

NM009870

Cyclin-dependent kinase 4

0.58

2.1E−05

BB623587

Integrin alpha 8

0.57

2.2E−02

NM011083

Phosphatidylinositol 3-kinase

0.54

1.1E−05

AF185285

Toll-like receptor 4

0.50

1.0E−02

NM133721

Integrin alpha 9

0.41

1.7E−02

NM010761

Cyclin D-type binding-protein 1

0.38

5.4E−03

AF124142

Thymoma viral proto-oncogene 3

0.35

1.4E−02

BG065754

Cyclin G1

0.32

1.8E−03

Regulation of Actin Cytoskeleton

NM011146

Peroxisome proliferator activated receptor gamma

1.42

4.9E−05

BM238906

NCK associated protein 1 like

0.86

2.3E−02

BC027242

Vav 3 oncogene

0.74

7.7E−03

BE372352

ARP3 actin-related protein 3

0.55

8.4E−07

NM011083

Phosphatidylinositol 3-kinase

0.54

1.1E−05

NM011072

Profilin 1

0.54

2.9E−02

AW537308

p21 protein (Cdc42/Rac)-activated kinase 2

0.36

1.4E−02

AK014859

ARP2 actin-related protein 2

0.33

2.2E−05

Focal Adhesions

BM935811

Integrin alpha 6

1.32

6.5E−08

NM010576

Integrin alpha 4

1.32

6.0E−03

NM009008

RAS-related C3 botulinum substrate 2

1.21

8.8E−04

BM246972

RAS related protein 1b

1.19

7.5E−09

BM940281

Mitogen-activated protein kinase 8

0.96

4.1E−04

BM120341

Integrin beta 1 (fibronectin receptor beta)

0.92

5.7E−06

NM008396

Integrin alpha 2

0.84

3.4E−03

BC027242

Vav 3 oncogene

0.74

7.7E−03

BC003828

RAS-related C3 botulinum substrate 1

0.70

1.0E−06

BB623587

Integrin alpha 8

0.57

2.2E−02

NM011083

Phosphatidylinositol 3-kinase

0.54

1.1E−05

NM011949

Mitogen-activated protein kinase 1

0.51

3.2E−05

BC011105

RAS-related protein-1a

0.47

8.0E−04

NM133721

Integrin alpha 9

0.41

1.7E−02

AW537308

p21 protein (Cdc42/Rac)-activated kinase 2

0.36

1.4E−02

AF124142

Thymoma viral proto-oncogene 3

0.35

1.4E−02

BC015289

Vasodilator-stimulated phosphoprotein

0.34

2.0E−02

  1. The table contains all the differentially expressed genes (DEGs) that resulted from the GSE40857 analysis. Log Fold Change ratio (logFC) and adjusted p-values (corrected by the Benjamini–Hochberg method [35]) are shown for each gene. logFC > 0 and an adjusted p-value < 0.05 indicate that the gene is upregulated in the ONC group