Skip to main content
Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Lactate attenuates astrocytic inflammation by inhibiting ubiquitination and degradation of NDRG2 under oxygen–glucose deprivation conditions

Fig. 8

Mechanism of neuroinflammation regulation by lactate via NDRG2 (N-Myc downstream-regulated gene 2) and TNFα. Phosphorylated c-Jun promotes the expression of TNFα, which exacerbates neuroinflammation and damages neighboring cells. However, lactate directly binds with NDRG2 and inhibits its ubiquitination and degradation. NDRG2 inhibits c-Jun phosphorylation and thus subsequently inhibits TNFα production. This finding suggests a valuable approach for modulating neuroinflammation during the early stages of ischemia (Created with www.BioRender.com)

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094