Fig. 5

Network diagram (a left panel) and Pathway Enrichment (a right panel) for the outcome-significant (mRS poor vs. good) for the 3hPurple module. In the a left panel, the network diagram shows the connectivity of hubs and genes within the module. Nodes represent genes within the module and edges represent connections based on co-expression between genes. Larger nodes with large labels are hub genes, representing potential master regulators. Genes are grey by default and colored if they are cell type specific. In the a right panel, the top 20 most significant relevant pathways are displayed. The significance threshold (P = 0.05) corresponds to the vertical black line. Blue shading indicates suppression and orange activation with darker colors representing larger |Z-score|. Grey represents no activity pattern available for the pathway in the IPA knowledge base. An asterisk * represents statistically significant activation or suppression (Z ≥ 2 or Z ≤ − 2) in poor outcome compared to good outcome. In b the Network diagram (b left panel) and Pathway Enrichment (b right panel) for the outcome-significant (mRS poor vs. good) for the 3hRoyalBlue module. The LAT gene is colored as T cell-specific though it is expressed in megakaryocytes and T cells. White bars represent activity pattern prediction of Z = 0 (suppression or activation status cannot be predicated). Other details of this figure are identical to those in a. Reg. regulation, GFs. growth factors, Expr. expression, Lymph. lymphocytes