Inhibitor/treatment | IL-6 | CXCL8 | CCL2 | |
---|---|---|---|---|
Bb 10:1/siRNA | FGFR1 siRNA (50 nM) | 1.725 (± 0.565) | 1.151 (± 0.082) | 1.212 (± 0.111) |
FGFR2 siRNA (50 nM) | 2.224 (± 0.916) | 1.214 (± 0.068) | 1.324 (± 0.151) | |
FGFR3 siRNA (50 nM) | 1.535 (± 0.325) | 1.274 (± 0.125) | 1.437 (± 0.321) | |
Medium/siRNA | FGFR1 siRNA (50 nM) | 0.973 (± 0.112) | 1.073 (± 0.044) | 1.439 (± 0.299) |
FGFR2 siRNA (50 nM) | 1.188 (± 0.070) | 1.194 (± 0.189) | 1.534 (± 0.258) | |
FGFR3 siRNA (50 nM) | 1.278 (± 0.165) | 1.571 (± 0.381) | 1.345 (± 0.123) | |
Bb 10:1/FGFR1 inhibitor PD166866 | 5 µM | 1.982 (± 0.394) | 1.954 (± 0.492) | 3.292 (± 1.056) |
2.5 µM | 1.850 (± 0.737) | 1.906 (± 0.683) | 2.769 (± 1.397) | |
1 µM | 1.703 (± 0.474) | 1.713 (± 0.543) | 2.077 (± 0.759) | |
500 nM | 1.071 (± 0.367) | 0.901 (± 0.226) | 1.113 (± 0.352) | |
Medium/FGFR1 inhibitor PD166866 | 5 µM | 0.880 (± 0.062) | 1.099 (± 0.110) | 2.322 (± 0.615) |
2.5 µM | 1.133 (± 0.133) | 1.213 (± 0.172) | 2.201 (± 0.417) | |
1 µM | 1.303 (± 0.048) | 1.217 (± 0.114) | 1.669 (± 0.125) | |
500 nM | 1.138 (± 0.129) | 1.012 (± 0.092) | 1.402 (± 0.119) | |
Bb 10:1/BGJ398 | 1 µM | 2.292 (± 0.140) | 2.046 (± 0.158) | 3.480 (± 0.568) |
500 nM | 2.403 (± 0.515) | 1.409 (± 0.233) | 1.836 (± 0.301) | |
Bb 10:1/AZD4547 | 10 µM | 3.817 (± 1.882) | 2.369 (± 1.173) | 6.034 (± 3.967) |
5 µM | 2.176 (± 0.921) | 2.048 (± 0.942) | 2.809 (± 1.495) | |
Medium/AZD4547 | 10 µM | 1.424 (± 0.937) | 1.929 (± 0.101) | 5.656 (± 1.626) |
5 µM | 2.170 (± 0.581) | 1.338 (± 0.214) | 2.432 (± 0.434) |