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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Directly targeting ASC by lonidamine alleviates inflammasome-driven diseases

Fig. 1

LND alleviates inflammatory injuries in experimental ischemic stroke and EAE. A The mice were subjected to MCAO and sham surgery for 1 h followed by intraperitoneal injection of LND (60 mg/kg) and 23 h of reperfusion. Behavioral scores after 23 h of reperfusion; n = 15. B and C Representative Nissl staining of brain sections (B) and quantification of the area of neuronal damage (C). n = 9. D EAE was induced in mice by MOG35 ~ 55 peptides and pertussis toxin as described in the Materials and methods. Clinical scores of mice administered vehicle or LND daily after EAE induction; n = 12. E Weight changes of mice after EAE induction; n = 12. F Representative H&E and Luxol Fast Blue (LFB) staining. Scale bar = 100 μm. G Percentage of CD45+ gated on live cells, and CD45+CD4+, CD45+CD8+ and CD45+CD11b+ cells gated on live cells from the mononuclear cell population in the CNS. The cells were isolated on day 15 after EAE induction. The data are expressed as the mean ± SEM *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; NS, not significant. Unpaired t test was used for A, C, D and E, and multiple unpaired t test for G

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